Table 2.
Minimum Inhibitory Concentrations against Gram-Positive bacteria measured under aerobic conditions, µg/mL.
| Anti-acne agent Bacteria |
antibiotics | non-antibiotics | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Vancomycin | Tetracycline | Erythromycin | Oxacillin | Clindamycin | Dapsone | Salicylic acid | Azelaic acid | Benzoyl peroxide 75% | |
| Staphylococci | |||||||||
|
S. aureus, MSSA ATCC 25923 |
1 | 0.25–0.5 | 1 | 0.125–0.25 | 0.125 | 256 | 32000 | 16000 | >2048–2048 |
|
S. aureus, MSSA ATCC 29213 |
1 | 0.5 | 1 | 0.25–0.125 | 0.06–0.03 | 512–1024 | 64000 | 16000 | 2048 |
|
S. aureus, MRSA ATCC 43300 |
1 | 0.25 | >32 | 16 | >32 | 128–256 | 32000 | 16000 | 2048 |
|
S. aureus, MRSA ATCC 33591 |
1 | >32 | >32 | >64 | >32 | >4100 | 64000 | 16000 | ≥2048 |
|
S. aureus, GISA NRS1 |
4 | 32 | >32 | >64 | >32 | 256–512 | 32000 | 8000 | 2048 |
|
S. aureus, VRSA VRS1 |
>64 | 1 | >32 | >64 | >32 | 512–025 | 32000 | 2000–16000 | 2048 |
|
S. capitis ATCC 27840 |
1–2 | 32 | 0.5 | 0.06–0.125 | 0.06–0.125 | 128 | 4000 | 8000–6000 | 2048 |
|
S. epidermidis ATCC 12228 |
1 | ≥32 | 0.5 | 0.125 | 0.06 | >4100 | 8000 | 8000 | 2048 |
|
S. epidermidis ATCC 14990 |
1/2 | 16–32 | 0.25–0.5 | 0.03–0.06 | 0.03 | 128 | 2000–4000 | 16000 | 2048 |
|
S. epidermidis, VISE NRS60 |
4 | 32 | >32 | 8 | ≤0.015 | 256–1025 | 8000–16000 | 8000–16000 | 2048 |
|
S. warneri ATCC 27836 |
1 | 0.5 | 0.5 | 0.5 | 0.03 | 4 | 32000 | 16000 | 2048 |
| Other organisms | |||||||||
|
B. cereus ATCC 11778 |
1 | ≤0.015 | 0.25 | >64 | 0.5 | 256 | 32000 | 8000–16000 | 2048 |
|
B. megaterium ATCC 13632 |
0.125 | 0.5 | 0.25 | 0.25–0.5 | 32 | 64 | 16000–32000 | 8000–16000 | 2048 |
|
B. subtilis ATCC 6633 |
0.06–0.125 | 0.06–0.125 | 0.125 | 0.25 | 1 | 4–8 | 32000 | 8000–16000 | 2048 |
|
E. faecium ATCC 35667 |
0.5–1 | 0.5–0.25 | 2–4 | 16 | ≤0.015 | >4100 | 32000 | 16000 | ≥2048 |
|
E. faecalis ATCC 29212 |
2 | 32 | 2–4 | 8 | 16 | 16 | 32000 | 16000 | 1024–2048 |
|
K. rosea ATCC 31251 |
1–2 | 32–16 | 0.25 | 0.06–0.12 | 0.03–0.06 | 128–256 | 2000 | 2000–16000 | 2048 |
|
M. luteus ATCC 4698 |
0.06–0.25 | 0.06–0.125 | 0.25 | 2–4 | 0.015–0.125 | 256 | 2000–4000 | 4000 | 1024 |
|
S. pneumoniae ATCC 33400 |
1 | 0.125–0.25 | 0.015–0.5 | 0.25 | 0.06 | 256–512 | 32000 | 8000 | 2048 |
|
S. pneumoniae, MDR ATCC 700677 |
1 | >32 | >32 | >64 | >32 | >4100 | 32000 | 16000 | 2048 |
|
S. pyogenes ATCC 14289 |
0.25–0.125 | 0.06 | ≤0.015 | ≤0.03 | ≤0.015 | ≤2 | 1000–2000 | 4000 | 2048 |
*[n = 4, duplicate results from 2 independent assays; MIC variations indicated. Bacterial species in bold are resistant.]