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. 2019 Oct 10;9:14664. doi: 10.1038/s41598-019-51140-w

Figure 1.

Figure 1

Effect of ghrelin on pain behavior exhibited on the ipsilateral and contralateral regions of rats after CCI. The baseline nociceptive threshold was similar in all groups. (A,B) In the CCI group, the ipsilateral TWL significantly decreased at day 3 and the MWT significantly decreased at day 1. This increased sensitivity to mechanical and thermal stimuli was sustained until at least day 14 after CCI. (B) The contralateral side showed no change compared with the sham group and the normal control rats. (C) To investigate the effect of ghrelin on CCI-associated NP, as reflected by mechanical and thermal hyperalgesia, we intrathecally administered ghrelin (3 µg) daily from day 1 to day 7 after CCI. Continuous intrathecal injection of ghrelin for 7 days significantly increased the TWL and MWT on the ipsilateral side compared with CCI only group and these effects lasted until 14 days after CCI surgery. (D) Neither CCI nor treatment with ghrelin affected the MWT or the TWL on the contralateral side. Results are presented as mean ± SD. n = 5. *p < 0.05, **p < 0.01 vs Sham group; #p < 0.05, ##p < 0.01 vs CCI group.