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. 2019 Oct 10;9:14656. doi: 10.1038/s41598-019-51084-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Structural organization of a CFA-induced granuloma and PrP^Sc detection in the adjacent lymphofollicular structure. Granulomas were induced in tg338 mice by two successive injections of CFA emulsified in PBS (50% vol/vol) injected subcutaneously into the abdominal or dorsal face of the animals. (A), Hematoxylin/eosin staining after formalin fixation and paraffin embedding. Slides were scanned using a Hamamatsu digital NanoZoomer. LFS, adjacent lymphoid structure; H, hair follicles. The marked area delineates the underlying magnified insert (panel B). Panels C and D represent immunofluorescence (IF) labeling of PrP^Sc of granuloma sections from 127 S-infected and uninfected control mice, respectively. The white arrowhead highlights the specific labeling of Sha31 within lymphofollicular zones surrounding the granuloma core.