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. 2019 Oct 4;13:440. doi: 10.3389/fncel.2019.00440

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Copyright © 2019 Carzoli, Sharfman, Lerner, Miller, Holmgren and Wills.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GluN2B transmission and NMDAR metaplasticity in adult male mice with a history of AIE following an ethanol challenge. (A) Protocol used to evaluate whether an ethanol challenge (single 16-h vapor chamber session, EtOH) given during a prolonged period of abstinence would re-engage NMDAR plasticity induced by AIE (AIE-EtOH) relative to air controls (Air-EtOH). (B) Time course of NMDAR-EPSC peak amplitudes following a 10-min application of Ro 25–6981. (C) Plot of the summation index across stimulation frequencies and treatments demonstrating that an alcohol re-exposure had no effect on the temporal summation of NMDA-EPSCs in adult males with a history of AIE. All data points indicate mean ± SEM.