Figure 1.

γδ T cells express an array of activating receptors for tumor cell recognition. Many of these mechanisms rely on the upregulation of stress ligands by tumor cells, including MICA/B (humans), Rae‐1/H‐60 (mouse) and ULBPs. γδ T cells also display an NK‐like phenotype in their expression of NCRs (NKp30, NKp44 and NKp46), particularly following activation. LFA‐1, lymphocyte function‐associated antigen 1; NKG2D, natural killer group 2 member D; PLZF, promyelocytic leukaemia zinc finger protein; Rae1, retinoic acid early inducible‐1; TCR, T‐cell receptor; TRAIL, TNF‐related apoptosis‐inducing ligand; ULBP, UL16‐binding proteins. * denotes expression on some clones only.