Table 1.

The relative anatomical distribution and primary effector functions of different γδ T‐cell subsets in humans and mouse

Subset	Common γ‐δ chain pairings	Anatomical localisation	Context for the production of IFN‐γ or IL‐17	Other effector molecules
Mousea
Vγ1	Vγ1Vδ6.3/6.4	Liver, secondary lymphoid organs	IFN‐γ – cancer,25 viral infection26	TNF, IL‐427
Vγ2	Undefined	Liver, lung (rare)	Undefined	Undefined
Vγ4	Vγ4Vδ4	Lung, liver, dermis, lamina propria, secondary lymphoid organs	IFN‐γ – cancer,28 IL‐17 – skin injury29	TNF, IL‐2230
Vγ5	Vγ5Vδ1 (DETC)	Epidermis	IFN‐γ – cancer, TLR signalling,31 NKG2D ligation31	TNF, IL‐2232
Vγ6	Vγ6Vδ1	Uterine epithelia, lung	IL‐17 – bacterial infection,33 cancer34	IL‐2235
Vγ7	Vγ7Vδ4/5/6	Gut epithelia	IFN‐γ – bacterial infection27	IL‐4, IL‐1027
Human
Vδ1	Undefined	Gut epithelia, liver, dermis	IFN‐γ – cancer,36 IL‐17 – colorectal cancer37	TNF,36 IL‐1023
Vδ2	Vγ9Vδ2	Peripheral blood	IFN‐γ – cancer, phosphoantigen stimulation8IL‐17 – bacterial infection24	TNF,21 IL‐9,22 IL‐1023
Vδ3	Undefined	Gut epithelia, liver	IFN‐γ – glycolipids38	TNF, IL‐438

Heilig and Tonegawa nomenclature.