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. 2019 Oct 4;10:2331. doi: 10.3389/fimmu.2019.02331

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Copyright © 2019 Messingham, Crowe and Fairley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Clinical and histologic characteristics of Bullous pemphigoid. (A) Clinical presentation of BP with tense, fluid filled blisters occurring on areas of erythema and normal skin, frequently associated with urticarial plaques. (B) Blisters correspond histologically to a subepidermal separation at the basement membrane zone (BMZ) with eosinophils observed in the superficial dermis and the blister cavity. H and E, 100x. (C) Eosinophils in the deep perivascular infiltrate in a lesional biopsy from a BP patient. H and E, 400x (Images in B, C are courtesy of Dr. Brian L. Swick, University of Iowa).