Table 1.
Association of serum IgE antibody levels with severity or phenotype of Bullous pemphigoid and eosinophilia as reported in primary literature1,2.
| Disease severity | Disease phenotype | Eosinophilia | |||||
|---|---|---|---|---|---|---|---|
| Positive association | No association | Urticarial | Nodular | None | Peripheral or lesional | None | |
| Total IgE | (33, 47, 49) | (45, 53) | (37) | (45) | (49) | (54) | |
| BP180 IgE ELISA |
(37, 41, 47, 49, 55–57) | (46, 58–60) | (57, 61) | (45, 50) | (37) | (49) | (50, 57, 60) |
| BP230 IgE ELISA |
(50, 62) | (46, 50, 56, 59) (negative association) | (50) | (46) | (50) | ||
1
Including case series, case control, cohort, and retrospective studies.
2
Total IgE was measured using a commercially available ELISA or by chemiluminescence at institutional reference labs. BP180- and BP230-IgE was measured using lab-specific protocols using either recombinant protein antigens made in-house or antigen-coated plates from a commercial BP180 IgG ELISA paired with an IgE-specific secondary antibody.