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. 2019 Oct 10;9:14661. doi: 10.1038/s41598-019-51092-1

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Milk EVs modulate cytokine production in the colon. Bio-Plex quantification of cytokines and chemokines in colon of healthy and colitic mice fed with milk EVs or the CS. Data are represented as a heatmap with clustering with median concentrations in pg/mL (inside the boxes) determined using a synthetic cytokine standard curve (n = 5/group randomly selected among n = 10 biological replicates). Abbreviations. CS, control solution; EVs, extracellular vesicles; P100K, pellet 100,000 g; P35K, pellet 35,000 g.