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. 2019 Oct 10;9:14602. doi: 10.1038/s41598-019-50888-5

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Assessment of inter- and intra-tumour heterogeneity of TIL burden in LMS. (A) Dot plot shows average CD3+, CD4+ and CD8+ TIL/HPF values for each of 47 LMS tumours (vertically aligned), with overall tumour value (+/−95% confidence interval) and individual constituent blocks values shown with in black and red respectively. Colour bars demonstrate maximum difference of any related tumour block from overall tumour average, with zero, cohort interquartile range (IQR), and maximum difference values shown on colour key for each lymphocyte marker. (B) Representative IHC images at x20 magnification demonstrate CD3+ TIL burden between the most and least densely infiltrated blocks from three tumours as indicated in (A). (C) Table summarising results from three separate 2-way ANOVA analyses that identifies the contribution of intra-tumour (block effect) and inter-tumour (tumour effect) variance to the overall total amount of variance in lymphocyte counts for CD3, CD4 and CD8 within the 47 LMS cohort.