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. 2019 Oct 10;9:14503. doi: 10.1038/s41598-019-51021-2

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes of fucosylated AGP levels in serum samples from patients treated with nivolumab. L-fAGP contains patients whose levels decreased below the cut-off value within one month (a) (No. 30) and a few months (b) (No. 36) and (c) (No. 34), and whose levels remained below the cut-off value (d) (No. 26). H-fAGP contains patients whose levels retained high (e) (No. 17), increased gradually within one month (f) (No. 11) and showed transiently decreased levels during one month (g) (No. 15) and (h) (No. 18). Numbers noted in brackets are patients’ numbers in Fig. 2. The solid line at 16.67 U/μg indicates the cut-off value in this study. fAGP, fucosylated AGP. A yellow-colored screen in each group indicates a period of one month after starting administration (see the details in Text).