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. 2019 Oct 10;9:14607. doi: 10.1038/s41598-019-51174-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Surface representation of ErmE. (a) ErmE surface colored according to sequence conservation calculated by ConSurf⁵⁵. The color spectrum ranges from magenta (highest conservation) to cyan (lowest conservation). (b) ErmE surface colored by electrostatic potential. The color spectrum ranges from deep red (−5 kT) to deep blue (+5 kT). The SAM binding site is indicated by a green ellipse.