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. 2019 Oct 10;9:14636. doi: 10.1038/s41598-019-51093-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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High-resolution of tumour stromal cells. (A) Image panel showing a RT2 tumour following implantation into a Tie2-EYFP host at indicated time-points. Tumour cells were visualized by scattered light (grey scale). Tumour vessels were visualized by EYFP expressed by endothelial cells (and through Texas Red-70 kDa dextran administered to the circulation (Texas Red) (red). Intratumour cavities, i.e. blood islands, filled by Texas Red dye but lacking endothelial lining were observed from week 3 (arrows). Bottom row represents merged images (n = 7). (B) The 3D image projections display the localization of intratumour cavities (yellow) in relation to the tumour vasculature. Scale bars represent 50 μm.