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. 2019 Oct 10;9:14573. doi: 10.1038/s41598-019-51151-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Nrf2^−/− mice can develop atrophic AMD-like phenotypes after mild light exposure. (A) The H&E histology showed the dry AMD phenotypes on light exposure induced Nrf2^−/− model. From left to right: vacuole, drusen-like deposit, and choroid vascular changes, Scale Bar 50 µm. (B) The TEM images showed the dry AMD phenotypes on light damaged Nrf2^−/− model. (White Arrow: vacuole, black arrow: drusen-like deposit, asterisk: lipofuscin granule, and star-shape: PRC cells detachment). Scale bar: 2 µm. Original images were presented in Supplementary Fig. S6.