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. 2019 Oct 10;9:14573. doi: 10.1038/s41598-019-51151-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GCCNP and GCCNP laden hydrogel provide structurally rescue in light-induced Nrf2^−/− mice retina degeneration. (A) Paraffin H&E histology studies exhibited 3 h 4500 lux damage treated by GCCNP and GCCNP laden hydrogel. (B) The Fundus and OCT images of Nrf2^−/− mice. 3 h 4500 lux light exposure groups treated by 1 µg GCCNP, 1 µL hydrogel, or 1 µg GCCNP in 1 µL hydrogel by intravitreal injection. (C) The retina ONL thickness (n = 5) measured by OCT and averaged thickness of retina ONL in all the groups by 1, 5, and 10 weeks. ONL thickness was rescued with GCCNP with/without hydrogel. Distance from ONH: 1.7 mm. (One-way ANOVA with Tukey’s multiple comparison test, error bars indicate SEM n = 5, *P < 0.05, **P < 0.01, ***P < 0.001).