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. 2019 Oct 10;9:14573. doi: 10.1038/s41598-019-51151-7

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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GCCNP and GCCNP laden hydrogel reduced AMD-like phenotypes on Nrf2^−/− mice. (A) TEM measured thickness of Bruch’s membrane. The light exposure caused irregular thicken BrM and GCCNP treated the thicken BrM. (B) The statistics of BrM thickness and lipofuscin granules number (One-way ANOVA, ***P < 0.001, n = 10).