Table 4.

Subgroup analyses of the associations between NLR and mortality in hemorrhagic stroke.

Stratified analyses	No. of patients	No. of studies	Model	Pooled HR (95%CI)	P-value	PD-value	Heterogeneity
							I2	PH-value
Assessment time						0.005
In-hospital mortality	1,129	2	Random	1.002 (0.933–1.076)	0.961		88.3%	0.003
30-day mortality	613	3	Random	1.384 (0.985–1.945)	0.061		85.4%	0.001
90-day mortality	1,720	4	Random	1.489 (1.068–2.075)	0.019		92.2%	<0.001
One-year mortality	593	2	Random	1.196 (0.817–1.750)	0.358		73.9%	0.050
Clinical characteristic
Hemorrhagic stroke subtypes						0.005
ICH	1,997	6	Random	1.090 (1.004–1.182)	0.039		85.7%	<0.001
SAH	929	3	Random	1.125 (1.002–1.263)	0.046		90.4%	<0.001
Hematoma size						0.005
<14 ml	737	3	Random	1.348 (1.067–1.702)	0.012		66.3%	0.052
≥14 ml	1,596	4	Random	1.061 (0.958–1.174)	0.255		90.5%	<0.001
Presence of IVH						0.024
<25%	389	2	Random	2.027 (0.857–4.798)	0.108		63.8%	0.096
≥25%	1,191	2	Random	1.025 (0.916–1.146)	0.670		93.3%	<0.001
Demographic factors
Age						0.011
<65	962	3	Random	1.112 (0.989–1.250)	0.076		90.1%	<0.001
≥65	1,645	5	Random	1.080 (0.997–1.170)	0.059		87.1%	<0.001
Gender distribution						0.005
Male dominant	1,301	5	Random	1.944 (1.281–2.951)	0.002		89.6%	<0.001
Balanced	855	1	Random	0.970 (0.950–0.991)	0.006		-	-
Female dominant	770	3	Random	1.051 (1.005–1.100)	0.030		55.8%	0.079
Country						0.005
Eastern	1,367	5	Random	1.115 (1.011–1.229)	0.029		86.5%	<0.001
Western	1,559	4	Random	1.083 (0.993–1.181)	0.072		87.5%	<0.001
Vascular risk factors
Presence of hypertension						0.005
<55%	274	1	Fixed	1.033 (1.012–1.054)	0.002		0.0%	0.678
≥55% and <65%	655	2	Random	2.743 (0.849–8.863)	0.092		90.6%	0.001
≥65% and <75%	609	3	Random	1.214 (1.035–1.425)	0.017		78.1%	0.010
≥75%	1,388	3	Random	0.978 (0.923–1.037)	0.458		68.3%	0.024
Presence of diabetes mellitus						0.011
<25%	1,752	7	Random	1.177 (1.072–1.291)	0.001		87.1%	<0.001
≥25%	855	1	Fixed	0.970 (0.950–0.991)	0.006		0.0%	0.740
Presence of hyperlipidemia						0.161
<25%	177	1	Random	1.160 (1.016–1.325)	0.028
≥25%	1,063	2	Random	1.034 (0.949–1.126)	0.449		90.4%	<0.001
Presence of current smoking						0.011
<35%	1,928	5	Random	1.158 (1.033–1.297)	0.011		91.6%	<0.001
Methodological factors
Sample time&						0.002
On admission	1,398	3	Random	1.003 (0.950–1.059)	0.916		74.7%	0.008
Within 24 h	1,254	5	Random	1.965 (1.313–2.941)	0.001		86.4%	<0.001
Cutoff value						0.026
<4	855	1	Fixed	0.970 (0.950–0.991)	0.006		0.0%	0.740
≥4	1,589	6	Random	1.626 (1.221–2.166)	0.001		85.2%	<0.001
Definition of cutoff value						0.005
ROC curve analysis	1,445	6	Random	1.547 (1.205–1.987)	0.001		87.0%	<0.001
4th quartile	1,207	2	Random	0.972 (0.940–1.005)	0.091		41.8%	0.179
Continuous variable	274	1	Fixed	1.033 (1.012–1.054)	0.002		0.0%	0.678
HR calculation						0.011
Multivariate	2,607	8	Random	1.080 (1.018–1.146)	0.011		88.7%	<0.001

ICH, intracerebral hemorrhage; SAH, subarachnoid hemorrhage; IVH, intraventricular hemorrhage.

^#Onset time was defined as time from stroke onset to recruitment/admission/diagnosis.

^&Sample time was defined as time from stroke onset to take blood sample.

^‡HRs were extracted from multivariate Cox proportional hazards models, univariate Cox proportional hazards models, or survival curve analysis.