Table 3.

Synthesis of the results of studies that evaluate the acute effect of combined aerobic exercise and blood flow restriction on hemodynamic variables in athletes, young adults, and elderly individuals.

References	Subjects	Variable	Exercise protocol			Intensity/frequency of training/study of duration	Exercise volume		Interval	PADE (mmHg)	BFR between sets	SW(cm)	Results
			EX	FE	VE		Series or continuous	Repetitions or duration time
Abe et al., 2006	18 Healthy youth	HR	WALK	TREADMILL	50 m/min		5 Sets	2 min	1 min	120–220	Yes	-	↑ HR during protocol with BFR
Abe et al., 2010a	19 Young men	HR	CYC	CYCLE	50 m/min	40% VO2maxBFR 40% VO2Max	Continuous	15 min with BFR 45 min without BFR	–	160–210	–	5.0	↑ HR in protocol with BFR
Renzi et al., 2010	17 men and women adults	HR, CO, DP and SBP	WALK	TREADMILL	3.21 Km/h	–	5-Sets	2 min	1 min	160	Yes	–	↑ HR, BP and DP and ↓ SV during training with BFR
Ozaki et al., 2010	10 Men	HR, CO, SBP, DBP, MAP, SV	CYC	CYCLE	–	0–20–40–60% VO2max with and without BFR	Continuous	4 min each stage	–	200	Yes	5.0	↑HR, CO, SBP, DBP, MAP and ↓ VEJ in training with BFR
Loenneke et al., 2011	10 Men and women	HR	WALK	TREADMILL	75 m/min	–	5 Sets	2 min	1 min	Elastic	Yes	7.6	↑HR in the exercise session with BFR
Kumagai et al., 2012	8 Men	HR, SBP, DBP, SV, BP, CO, TPR	CYC	BICYCLE	–	40% VO2max with and without BFR	Continuous	30 min	-	200	Yes	5.0	↑ HR BFR and CON ↑ SBP and DBP in training with BFR until 10 min
Karabulut and Garcia, 2015	34 Obese men and women	HR, SBP, DBP	CYC	CYCLE	50 rpm	40% + BFR 60% + BFR without BFR 50 Watts	2 Sets	10 min	1 min	40%60%	Yes	5.0	↑ > HR and SBP in BFR protocols
Sugawara et al., 2015	15 Adult men and women	HR, SBP, DBP, SV, CO, TPR	WALK	TREADMILL	3.21 Km/h	WALK + BFR WALK	5 Sets	2 min	1 min	160	Yes	–	↑ > HR, SBP in protocol with BFR. SV and TPR is > for the control
Ferreira et al., 2016	21 Elderly men and women	HR, SBP, DBP, DP, SV, TPR, CO	WALK	TREADMILL	–	40% VO2maxBFR 40% VO2max 70% VO2Max	Continuous	20 min	–	50%	Yes	17.5	↑ HR and SBP in protocols BFR. DP in the protocol HI > LI and LI+BFR
Cirilo-Sousa et al., 2017	13 Men	HR, SBP, DBP	RUN	STATIONARY	–	50% HRMáx+BFR 50% HRMáx	5 Sets	2 min	1 min	80%	No	18	↑ HR, SBP and DBP in protocol with BFR
Conceição et al., 2018	12 Men	HR	CYC	CYCLE	60–70 rpm	40% VO2Max + BFR 40% VO2Max	Continuous	30 min	–	80%	No	18	↑ HR in protocol AE+BFR
Thomas et al., 2018	18 Men	BP, HR, CO	CYC	CYCLE	–	HI LI LI + BFR	3 Sets	2 min	2 min active	80%	Yes	10	↑BP, HR, CO in protocol HI > LI + BFR and LI BP, HR, CO in protocol LI + BFR > LI
Barilli et al., 2018	18 Elderly women	HR, SBP, DBP	WALK	TREADMILL		HIAE LI LI+BFR	Continuous	–	–	130% SBP rest	Yes	9.5	HR, SBP, and DPB in protocol HIAE = LI + BFR
Silva et al., 2018	23 Men	HR, SBP, DBP	RUN WALK	TREADMILL		HIIE AE + BFR AE	6 sets continuous	90 s 18 min	90 s active-	50%	No	18	↓ SBP, DPB in protocol HIIE and AE + BFR
Silva et al., 2019	22 Men	HR	RUNWALK	TREADMILL		HIIE AE + BFR AE	6 set Continuous	90 s 18 min	90 s active	50%	No	18	↑HR in protocol HIIE But, AE + BFR > AE

BFR, blood flow restriction; HR, heart rate; BP, blood pressure; SBP, systolic blood pressure; DBP, diastolic blood pressure; TPR, total peripheral resistance; CO, cardiac output; SV, stroke volume; DP, double product; EX, exercise; FE, form of exercise; VE, velocity of exercise; RPM, rotations per minute; WALK, walking; CYC, cycling; RUN, running; CYCLE, cycle ergometer; min, minutes; s, seconds; CON, Control; PADE, pressure applied during exercise; SW, sleeve width; –, Not informed; ↑, significant increase; LI + BFR, low intensity combined with blood flow restriction; LI, low intensity; HI, high intensity.