Table 3. Switching antipsychotics based on risk of adverse effects.
| Adverse effect | Recommended order of replacement drug (listed from lower to higher risk of adverse effect) |
|---|---|
| Extrapyramidal effects | Clozapine Quetiapine Olanzapine (low-dose) Aripiprazole Brexpiprazole Ziprasidone |
| Anticholinergic effects | Risperidone Paliperidone Ziprasidone Asenapine Lurasidone Haloperidol Aripiprazole Brexpiprazole |
| Weight gain | Haloperidol Ziprasidone Lurasidone Aripiprazole Amisulpride Asenapine |
| Postural hypotension | Haloperidol (oral and decanoate) Periciazine Flupentixol Amisulpride Aripiprazole |
| Hyperprolactinaemia | Aripiprazole Asenapine Quetiapine Clozapine Ziprasidone Olanzapine (low-dose) |
| QTc prolongation | Lurasidone Aripiprazole Paliperidone Haloperidol |
| Sedation | Amisulpride Paliperidone Aripiprazole Brexpiprazole |
| Sexual dysfunction | Aripiprazole Brexpiprazole Quetiapine (conflicting evidence) |