Table 1.
Genes in the amylin, insulin and leptin signalling pathways targeted by the NanoString nCounter analysis.
| Gene Target | |
|---|---|
| Adrbk1 (β-adrenergic receptor kinase 1) | Irs1 (insulin receptor substrate-1) |
| Agrp (agouti-related peptide) | Irs2 (insulin receptor substrate-2) |
| Akt1 | Jak2 (janus kinase 2) |
| Akt2 | Lepr (leptin receptor) |
| Amylin | Lepr-b (leptin receptor b) |
| Arrb1 (β-arrestin 1) | Mc4r (melanocortin 4 receptor) |
| Arrb2 (β-arrestin 2) | Mch (melanin concentrating hormone) |
| Calcr (calcitonin receptor) | mTor (mammalian target of rapamycin complex) |
| Calcr-1a (calcitonin receptor 1a) | Npy (neuropeptide Y) |
| Calcr-1b (calcitonin receptor 1b) | Pde3b (phosphodiesterase 3B) |
| Cart (cocaine and amphetamine regulated transcript) | Pdk1 (3-phosphoinositide dependent kinase-1) |
| c-Fos | Pias3 (protein inhibitor of activated STAT 3) |
| Foxo1 (foxhead box protein O1) | Pik3ca (phosphoinositide-3 kinase catalytic subunit a) |
| Gsk3a (glycogen synthase kinase 3a) | Pik3r1 (phosphoinositide-3 kinase regulatory subunit 1) |
| Gsk3b (glycogen synthase kinase 3b) | Pomc (pro-opiomelanocortin) |
| Hcrt (orexin) | Ptp1b (protein tyrosine phosphatase 1B) |
| Hdac5 (histone deacetylase 5) | Ramp1 (receptor activity modifying protein 1) |
| Hdc (histidine decarboxylase) | Ramp2 (receptor activity modifying protein 2) |
| Hrh1 (histamine receptor H1) | Ramp3 (receptor activity modifying protein 3) |
| Ins1 (insulin 1) | Socs3 (suppressor of cytokine signalling 3) |
| Ins2 (insulin 2) | Stat3 (signal transducer and activator of transcription 3) |
| Ir (insulin receptor) | |