Figure 3.

Electrophysiological recording of ChIs from the systematic Btbd9 KO mice and their WT littermates. A, Representative responses to the injected currents at 200 pA of KO (n = 20) and WT (n = 14) ChIs. B, The frequency-current relationship for KO and WT ChIs. KO showed decreased firing frequency compared with the WT. WT was normalized to 0 in log transformation. C, Representative traces of spontaneous firings of KO (n = 19) and WT (n = 17) ChIs. D, Btbd9 KO mice had decreased firing frequency, but no change in firing regularity in ChIs. GEE model normalized the WT group in the bar graph of B to 0 without the error bars. Data in D were presented as median with 95% CI. CV: coefficient of variance; *p < 0.05.