Table 1.

Comparing 3 reported cases of hepatotoxicity secondary to ibrutinib

Case No.	1	2	3
Underlying illness	Chronic lymphocytic	Waldenstrom's	Waldenstrom's
	leukemia	macroglobulinemia	macroglobulinemia
Age, years	62	59	77
Sex	Male	Female	Female
Abnormal liver function test onset	2 weeks	36 weeks	8 weeks
ALT peak, U/L	1,245	~800	1,747
AST peak, U/L	448	~3,000	1,300
Total bilirubin peak, mg/dL	35.2	13.6	20.4
INR peak	Not specified	7.7	1.5
Liver biopsy	Hepatocellular injury +	Hepatocellular injury +	Hepatocellular injury +
	cholestasis	cholestasis	cholestasis
Recovery time	12 weeks +	9 weeks	7 weeks
Outcome	Died from original illness	Full recovery	Full recovery