Figure 5.

Glucocorticoid‐mediated suppression of diabetes‐induced galectin‐1/Lgals1 expression with AKT/AP‐1 and ERK/AP‐1 activation in the mouse retina. (A‐C) Retinal Lgals1 (A) and Dusp1 (B) expression in mice with STZ‐induced diabetes at 2 mo. Dexamethasone (Dex, 50 pmol/eye) or triamcinolone acetonide (TA, 50 pmol/eye) were injected intravitreally to STZ mice, followed by mRNA (A,B) and protein (C) expression analyses after 24 h. *P < .05, **P < .01, n = 6‐8 per group. C, Immunoblot analyses for galectin‐1, DUSP1 and phosphorylated and total forms of AKT, ERK1/2 and AP‐1 subunits in the retina of diabetic mice treated with Dex or TA