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. 2019 Aug 19;23(10):7043–7053. doi: 10.1111/jcmm.14603

Figure 2.

Figure 2

Histology of lung lesions in D1CC mice 10 months after injection with bovine type II collagen (bCII). Paraffin‐embedded lung serial sections were stained with haematoxylin and eosin (HE) (A, B, D, H) or elastica Masson‐Goldner (EMG) (C, I) or immunostained for B cells (E), T cells (F) or macrophages (G). (A) Low‐power view of a lung lesion from a D1CC mouse. Arrows denote the lymphatic distribution of inflammatory changes along with the bronchovascular bundles. (B, C) Active inflammatory lesions in the peribronchial area (white star) as high‐magnification images (HE and EMG, respectively) of the area in the black rectangle in (A). The black arrows in (B, C) point to the bronchial epithelium. (D‐G) Inflammatory cell‐infiltrated lesions in the perivascular area (red stars) in a high‐magnification image of the area in the blue rectangle in (A). The inset in (D) shows a high‐magnification image of the area in the blue rectangle in (D). Infiltrated inflammatory cells are granulocytes (yellow arrow, inset; D) and B lymphocytes (E), T lymphocytes (F) and macrophages (G), as highlighted by brown staining. (H) Infiltration of inflammatory cells in a patchy distribution in the alveolar area surrounding the bronchi (black arrows). (I) Intraluminal fibrotic change (blue arrow) with inflammatory cells observed in this high‐magnification image of the area in the black rectangle in (H). Scale bars, 500 (A, H), 100 (B, C, I) and 50 µm (D‐G)