Figure 2.

Circ_0136474 could bind to the miR‐127‐5p and suppress its expression. A, Visualization of 20 different miRNAs between normal cartilage tissues and OA cartilage tissues and miR‐127‐5p was significantly down‐regulated in OA. B, The predicted targeted relationship between Circ_0136474 and miR‐127‐5p using Circular RNA Interactome (https://circinteractome.nia.nih.gov/ ). Dual‐luciferase reporter gene assay verified the targeted relationship between Circ_0136474 and miR‐127‐5p. C, p‐circ could greatly up‐regulate the expression of Circ_0136474, which could be instead suppressed with the silencing of Circ_0136474. D, Overexpression of Circ_0136474 could greatly suppress the expression of miR‐127‐5p, which could otherwise be reversed with the knockdown of Circ_0136474. **P < 0.01 meant that there was a significant difference compared with NC group