Figure 4.

Circ_0136474 affected cell apoptosis and proliferation by down‐regulation of miR‐127‐5p. A, B, Si‐circ and miR‐127‐5p mimics reduced the cell apoptotic rate in OA cartilage tissues, while p‐circ and inhibitor enhanced the cell apoptotic rate markedly. C, The results of cell proliferation showed that si‐circ and miR‐127‐5p mimics could promote the cell proliferation and p‐circ or miR‐127‐5p inhibitor could suppress the cell proliferation while it was reverted by co‐transfection of si‐circ and inhibitor. D, E, The detection of expression level of apoptosis‐related proteins was included to ensure the effects on cell numbers in cell apoptosis were direct. *P < 0.05 and ** P < 0.01 showed there was a significant difference compared with NC group