Figure 6.

Circ_0136474 inhibited miR‐127‐5p to promote MMP‐13 expression in OA cartilage tissues. A, Si‐MMP‐13‐1 and si‐MMP‐13‐2 reduced cell apoptotic rate in OA cartilage tissues. B, The results of cell proliferation rate showed that si‐MMP‐13‐1 and si‐MMP‐13‐2 could promote the cell proliferation, while it was reverted by co‐transfection of inhibitor and si‐MMP‐13. C, It was verified that si‐MMP‐13‐1 and si‐MMP‐13‐2 could down‐regulate the expression of MMP‐13, which could be rescued to normal level with co‐transfection of inhibitor. D‐G, Relative expression of collagen type II, IL‐1β, TNF‐α and IL‐17 was performed via qRT‐PCR. *P < 0.05 and ** P < 0.01 showed that there was a significant difference compared with NC group