Table 2. . Subgroup analyses of pooled hazard ratios for progression-free survival.
| Subgroups | Studies (n) | Pooled HR (95% CI) | I2 (%) | p-value |
|---|---|---|---|---|
| Age <65 years | 4 | 0.59 (0.38–0.84) | 66% | 0.0001 |
| Age ≥65 years | 4 | 0.65 (0.56–0.75) | 0% | 0.00001 |
| Male | 4 | 0.69 (0.62–0.78) | 0% | 0.00001 |
| Female | 4 | 0.48 (0.33–0.70) | 70% | 0.0001 |
| ECOG PS 0 | 4 | 0.59 (0.49–0.71) | 0% | 0.0001 |
| ECOG PS 1 | 4 | 0.66 (0.58–0.74) | 0% | 0.00001 |
| Smoking (current or former) | 3 | 0.64 (0.56–0.73) | 19% | 0.00001 |
| Smoking (never) | 3 | 0.55 (0.38–0.81) | 64% | 0.002 |
| PD-L1 <1% (negative) | 7 | 0.69 (0.60–0.79) | 35% | 0.00001 |
| PD-L1 ≥1–49% (low) | 6 | 0.64 (0.55–0.74) | 0% | 0.00001 |
| PD-L1 ≥50% (high) | 6 | 0.47 (0.38–0.57) | 0% | 0.00001 |
ECOG: Eastern Cooperative Oncology Group; HR: Hazard ratio; PD-L1: Programmed death ligand 1.