Table 2. . Serum IL-18 level according to conventional prognostic factors.

Factor		Serum IL-18			Serum sIL-2R
		Median	Range	p-value	Median	Range	p-value
All patients		10.8	3.8 – 231.7		468.8	67.5 – 2362.6
Gender	Males	10.8	3.8 – 231.7	0.739	456.8	67.5 – 2331.6	0.955
	Females	10.8	4.8 – 110.5		468.8	94.8 – 2362.6
Age	≤60	9.9	3.8 – 159	0.052	355.3	67.5 – 2362.6	<0.001
	>60	13.5	5.8 – 231.7		1145.7	98.7 – 2331.6
PS	0 or 1	10.6	3.8 – 231.7	0.465	454.7	67.5 – 2362.6	0.594
	2 – 4	11.0	5.6 – 86.5		468.8	104.3 – 2096.2
LDH	Normal	8.5	3.8 – 110.5	0.017	330	67.5 – 1942.2	<0.001
	Elevated	12.8	4.8 – 231.7		799.2	104.3 – 2362.6
Number of extranodal sites	0 or 1	10.9	3.8 – 231.7	0.243	422.7	67.5 – 2231.6	0.078
	≥2	9.3	5.6 – 28.5		766.4	478.8 – 2362.6
Clinical stage	I, II	9.0	3.8 – 110.5	0.066	350.0	67.5 – 1942.2	0.001
	III, IV	12.8	4.8 – 231.7		799.2	104.3 – 2362.6
IPI	L	8.9	3.8 – 110.5	0.615	310.9	67.5 – 1942.2	<0.001
	LI	12.1	5.8 – 159		725.6	104.3 – 1990.5
	HI	13.5	5.6 – 231.7		1819.6	541.8 – 2362.6
	H	22.2	9.3 – 79.1		1989.2	478.8 – 2080
B symptom	(−)	10.9	3.8 – 159	0.949	376.8	94.8 – 2231.6	0.036
	(+)	10.6	4.8 – 231.7		725.6	67.5 – 2362.6
Bulky sites	(−)	9.9	3.8 – 231.7	0.231	451.8	67.5 – 2362.6	0.171
	(+)	13.8	4.8 – 79.1		598.0	171.7 – 2231.6
HCV Ab	(−)	8.63	3.8 – 159	0.438	414.7	67.5 – 2080	0.069
	(+)	13.8	5.6 – 231.7		725.6	98.7 – 2362.6

Values in bold highlight variables with significant p value.

HCV Ab: Hepatitis C virus antibodies; IPI: International prognostic index; LDH: LDH level; PS: Performance status.