Table 3. . Remission rate and survival outcome according to serum levels IL-18 and sIL-2R and other prognostic factors.
| Factor | Number | CR rate | 3-year DFS | 3-year OS | ||||
|---|---|---|---|---|---|---|---|---|
| Percentage | p-value | Percentage | p-value | Percentage | p-value | |||
| Serum IL-18 (ROC) | ≤11.3 pg/ml | 39 | 79.5 | 0.339 | 49.3 | 0.279 | 62.9 | 0.153 |
| >11.3 pg/ml | 34 | 69.7 | 66.2 | 72.1 | ||||
| Serum IL-18 (mean) | ≤22.2 pg/ml | 60 | 76.7 | 0.465 | 72.1 | 0.127 | 77.8 | 0.008 |
| >22.2 pg/ml | 13 | 66.7 | NR | 55.4 | ||||
| Serum IL-18 (median) | ≤10.8 pg/ml | 37 | 78.4 | 0.496 | 40.9 | 0.126 | 54.8 | 0.280 |
| >10.8 pg/ml | 36 | 71.4 | 70.1 | 73.7 | ||||
| Serum sIL-2R | ≤592.4 U/ml | 44 | 90.9 | 0.001 | 75.4 | 0.007 | 95.4 | 0.001 |
| >592.4 U/ml | 29 | 50.0 | 35.4 | NR | ||||
| Gender | Males | 44 | 79.5 | 0.264 | 53.4 | 0.131 | 68.1 | 0.854 |
| Females | 29 | 67.9 | 93.3 | 86.1 | ||||
| Age | ≤60 | 52 | 80.4 | 0.100 | 67.4 | 0.581 | 83.9 | 0.124 |
| >60 | 21 | 61.9 | 55.0 | 49.8 | ||||
| PS | 0 or 1 | 58 | 78.9 | 0.132 | 65.0 | 0.385 | 72.7 | 0.116 |
| 2–4 | 15 | 60 | NR | 71.8 | ||||
| LDH | Normal | 31 | 87.1 | 0.039 | 69.8 | 0.975 | 100 | 0.014 |
| Elevated | 42 | 65.9 | 36.0 | 59.0 | ||||
| Number of extranodal sites | 0 or 1 | 68 | 77.9 | † | 60.5 | † | 74.3 | 0.038 |
| ≥2 | 5 | 25.0 | NR | NR | ||||
| Clinical stage | I, II | 37 | 86.5 | 0.021 | 81.5 | 0.008 | 82.6 | 0.012 |
| III, IV | 36 | 62.9 | NR | 61.4 | ||||
| IPI | L | 34 | 88.2 | 0.003 | 85.3 | † | 97.0 | 0.001 |
| LI | 21 | 76.0 | NR | 55.6 | ||||
| HI | 12 | 45.5 | NR | 55.6 | ||||
| H | 6 | 0.0 | NR | NR | ||||
| B symptoms | (−) | 48 | 77.1 | 0.564 | 65.5 | 0.053 | 84.8 | 0.010 |
| (+) | 25 | 70.8 | 56.9 | 55.4 | ||||
| Bulky sites | (−) | 60 | 79.7 | 0.052 | NR | 0.314 | 69.9 | 0.414 |
| (+) | 13 | 53.8 | 83.3 | 68.4 | ||||
Values in bold highlight variables with significant p value.
†
p-value cannot be calculated because of small numbers within some strata.
DFS: Disease-free survival; IPI: International prognostic index; LDH: LDH level; PS: Performance status; NR: Not reached; OS: Overall survival; ROC: Receiver operating characteristic.