Figure 4.

Course of urinary sodium/creatinine ratio from Con and Nphs2^∆pod treated with amiloride. Daily urinary sodium/creatinine ratio of control (Con) and Nphs2^∆pod treated with vehicle or amiloride (10 µg/g ip) during 14 days. Urine was collected 4 hours after injection of vehicle or amiloride. tam indicates the days of tamoxifen injection to induce Nphs2 knockout. Results are arithmetic means ± SEM of n = 5‐7 per group; *P < 0.05 Nphs2^∆pod/vehicle versus control/vehicle; ^# P < 0.05 Nphs2^∆pod/amiloride versus control/amiloride; and ^§ P < 0.05 control/amiloride versus control/vehicle