Table 6.
Median and 25–75 IQR calculated from a combined class of healthy control and mild ME/CFS cases (WST 0), moderate (WST 1) and severe (WST 2) symptoms correctly predicted by Random Forest Analysis (RFA). ME/CFS was diagnosed via the International Consensus Criteria [12], and WST class calculated from standing test results.
| Blood/Serum/Urine Marker | Weighted Standing Time Median (25th–75th) | p-Value * | ||
|---|---|---|---|---|
| WST 0 (n = 23) | WST 1 (n = 23) | WST 2 (n = 12) | ||
| MCH (pg) | 30.8 (29.8–31.5) | 29.5 (28.6–30.3) | 30.95 (30.2–32.25) | (a) 0.006 (b) 0.811 |
| Lymphocytes (×109/L) | 1.9 (1.5–2.3) | 1.9 (1.4–2.1) | 2.5 (2.1–3.0) | (a) 0.004 (b) 0.094 |
| Serum Urea (mmol/L) | 5.4 (4.6–6.4) | 5.4 (3.9–5.9) | 4.2 (3.83–4.58) | (a) 0.012 (b) 0.010 |
| ALP (U/L) | 60.0 (52.0–74.0) | 79.0 (67.0–86.0) | 50.5 (34.75–72.5) | (a) <0.001 (b) 0.840 |
| Urinary Creatinine Excretion Rate (mmol/24 h) | 13.1 (12.12–15.6) | 10.50 (7.5–11.4) | 10.45 (9.7–11.23) | (a) <0.001 (b) 0.001 |
| Activin B (pg/mL) | 130.36 (97.03–171.45) | 81.48 (71.53–106.47) | 93.86 (76.46–132.01) | (a) 0.004 (b) 0.013 |
* p-value set at p < 0.05 (Bonferroni correction not required for Kruskal–Wallis tests). p-values (a) Kruskal Wallis test (b) Jonckheere–Terpstra Test. IQR (Inter-Quartile Range).