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. 2019 Jul 9;7(3):14. doi: 10.3390/jdb7030014

Figure 1.

Figure 1

Model of asymmetric Hedgehog (Hh) activation maintaining discrete compartmental identity. We propose that differential activation of Hh is a possible mechanism in maintaining compartmental-specific identity and function in the lung. Loss of endogenous inhibitors of Hh activation could disrupt the physiological asymmetry of Hh, and lead to altered compartmental identity and structural alteration seen in lung diseases.