Figure 4. Expression of genes associated with protein synthesis and degradation signaling pathway in the soleus (A) muscle and in the EDL (B) muscle. Data are reported as means±SE, n=5–6 animals. The results were compared using two-way ANOVA and Bonferroni post hoc test. Ab and Ba are P<0.05 for C and Cr groups vs C-HS and Cr-HS groups (main effect of HS), using two-way ANOVA only (no statistical differences using the Bonferroni post hoc test). Bb is P<0.05 for C and HS groups vs Cr and Cr-HS groups (main effect of creatine), using two-way ANOVA only (no statistical differences using the Bonferroni post hoc test). C: control group; HS: hindlimb suspension group; Cr: creatine supplemented group; Cr-HS: creatine supplemented and hindlimb suspension group.
