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. 2019 Sep 17;42(5):1689–1698. doi: 10.3892/or.2019.7320

Figure 2.

Figure 2.

MicroRNA-4712-5p is upregulated in VSCC tissues and cells and promotes the proliferation and invasion of VSCC. RT-qPCR was conducted to determine the expression levels of miR-4712-5p; CCK-8 assay was used to detect the effect of miR-4712-5p on the proliferation of VSCC cells; Transwell assay demonstrated the invasiveness of cell lines transfected with miR-4712-5p mimics. (A) Expression levels of miR-4712-5p in 56 pairs of VSCC tissue and adjacent normal tissue; (B) expression levels of miR-4712-5p in VSCC cells and VECs; (C) transfection efficiency of A431 cells transfected with miR-4712-5p mimics; (D) effect of miR-4712-5p on the proliferation of VSCC cells; (E) invasiveness of cell lines transfected with miR-4712-5p mimics (magnification ×200, scale bar=100 µm); *P<0.05. VSCC, vulvar squamous cell carcinoma; RT-qPCR, reverse transcription-quantitative polymerase chain reaction; VECs, vaginal epithelial cells; NC, negative control.