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. 2019 Sep 17;42(5):1793–1804. doi: 10.3892/or.2019.7319

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Copyright: © Kučera et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — Detection of selected markers in normal HFP4 fibroblasts and CAFs isolated from a melanoma skin metastasis. Selected markers are visualised in primary culture of (A) normal dermal fibroblasts (HFP4) and (B) CAFs isolated from MM (MAM; ZAM data not shown). All types of fibroblasts expressed vimentin (data not shown). CAFs expressed more CXCR1 and CXCR2 than was observed in the normal fibroblasts (HFP4). Scale bar, 100 µm. CAFs, cancer-associated fibroblasts; CXCR1, C-X-C motif chemokine receptor 1; CXCR2, C-X-C motif chemokine receptor 2; VEGF, vascular endothelial growth factor; VEGF-AR1, VEGF-A receptor 1; VEGF-AR2, VEGF-A receptor 2; IL-6R, IL-6 receptor; NC, normal control.