Figure 7.

Effect of 3D structure formation on cell reaction to in vitro drug treatment (cell cycle distribution): (A) ACHN cells cultured on poly-D-lysine-coated surface in 3D media and standard monolayer or (B) Caki-1 cells cultured on laminin-coated surface in 3D media and standard monolayer. *P<0.05 vs. 2D; using Mann-Whitney U test; n=2 wells. y-axis represents % of control, untreated cells in respective culture variant. Epi, epirubicin at 1 µM; Su1, sunitinib at 1 µM; Su10, sunitinib at 10 µM.