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. 2019 Oct 11;20:588. doi: 10.1186/s13063-019-3695-7

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) figure. Schedule of enrolment, interventions, and assessment. ¹The 3-week follow-up includes a 1-week tapering down and a 2-week follow-up with no medication. Telephone call after the 3-week follow-up. In the case of unresolved side effects at this call, an additional call is scheduled after 1–4 weeks. ²Patients treated with pregabalin will come for an extra visit. ECG electrocardiogram, PGIC Patient Global Impression of Change