Table II.

Functional roles of the 10 hub genes with a degree ≥10.

No.	Gene symbol	Full name	Function
1	VEGFA	Vascular endothelial growth factor A	Induction of proliferation and migration of vascular endothelial cells; essential for both physiological as well as pathological angiogenesis.
2	BAX	BCL2-associated X, apoptosis regulator	It acts as either an anti- or proapoptotic regulator and is involved in several cellular activities.
3	CALM1	Calmodulin 1	Expression of a member of the EF-hand calcium-binding protein family
4	CALM2	Calmodulin 2	Role in proliferation, cell cycle progression, and signaling cascades.
5	CALM3	Calmodulin 3	Calcium binding; enzymatic co-factor; role in cell cycle regulation as well as cytokinesis.
6	FN1	Fibronectin 1	Fibronectin expression; involvement in cell adhesion and migration processes.
7	PRKCA	Protein kinase C α	Essential roles in numerous cellular processes, including cell volume control, checkpoints of the cell cycle, cell adhesion, as well as cell transformation.
8	IGF1	Insulin-like growth factor 1	Expression of protein with similar structure as well as function to insulin; member of a family of proteins involved in regulating growth and development.
9	RB1	RB transcriptional corepressor 1	Expression of negative regulatory protein of the cell cycle; the first tumor suppressor gene to be identified.
10	DES	Desmin	Expression of a muscle-specific class III intermediate filament. Homopolymers of this protein form a stable intracytoplasmic filamentous network which connects myofibrils to each other as well as to the plasma membrane.