Proliferation in PC-9 cells with PLAC8 knockdown and overexpression following U0126 treatment. Cell proliferation in (A) PLAC8-shRNA and control groups and (B) PLAC8-overexpressing and control groups of PC-9 cells, following treatment with 5 µM U0126 (red) or untreated (black). *P<0.05. PLAC8, placenta-specific protein 8; KDNC, knockdown negative control; OENC, overexpression negative control; sh, short hairpin.