Skip to main content
. 2019 Aug 7;14(12):2147–2155. doi: 10.4103/1673-5374.262593

Figure 3.

Figure 3

Effect of AAV5-CaMKII-CHR2-mCherry on memory in mice.

Using the novel object recognition test, working, and short-term and long-term memories were assessed with the memory index during the test phase (consolidation), 5 minutes, 2 hours and 24 hours after the training phase (M1, M2 or M3). Data are expressed as the mean ± SEM (n = 8). **P < 0.001, vs. Aβ-CHR2 group; ##P < 0.001, vs. M0 (one-way analysis of variance). Aβ: Repeated Aβ1–42 injection into the bilateral dentate gyrus; Aβ-non-CHR2: Repeated Aβ1–42 injection into the bilateral dentate gyrus together with AAV5-CaMK-mCherry injection and light stimulation; Aβ-CHR2: repeated Aβ1–42 injection into the bilateral dentate gyrus together with AAV5-CaMK-CHR2-mCherry injection and light stimulation. Memory index (%) = (exploring time for novel object B/total exploring time for object A1 and object B) × 100%. AAV: Adeno-associated virus; CaMK: Ca2+/calmodulin-dependent protein kinase; CHR2: channelrhodopsin-2.