Table 3.
IC50 of each cell line in response to Tamoxifen, Doxorubicin, or their combination. “IC50-STD” represents the standard deviation of IC50. “AdKu” represents the stable cell line we established with reduced ANLN and increased KDR gene expression.
| Cell line | Drug | IC50 | IC50-STD |
|---|---|---|---|
| MCF10A | Tamoxifen | 16.245 | 0.3269 |
| MCF7 | Tamoxifen | 25.4251 | 1.2181 |
| AdKu | Tamoxifen | 29.7514 | 1.4571 |
| MDAMB231 | Tamoxifen | 48.1855 | 2.393 |
| MCF10A | Tamoxifen + 10 nm Doxorubicin | 12.9009 | 0.3451 |
| MCF7 | Tamoxifen + 10 nm Doxorubicin | 36.3579 | 2.9832 |
| AdKu | Tamoxifen + 10 nm Doxorubicin | 39.0639 | 2.8264 |
| MDAMB231 | Tamoxifen + 10 nm Doxorubicin | 42.4501 | 3.1901 |
| MCF10A | Tamoxifen + 150 nm Doxorubicin | 0.3773 | 0.5591 |
| MCF7 | Tamoxifen + 150 nm Doxorubicin | 0.6219 | 1.0033 |
| AdKu | Tamoxifen + 150 nm Doxorubicin | 3.3216 | 2.9751 |
| MDAMB231 | Tamoxifen + 150 nm Doxorubicin | 39.9377 | 3.2996 |
| MCF10A | Doxorubicin | 154.4694 | 10.7738 |
| MCF7 | Doxorubicin | 184.7564 | 13.1385 |
| AdKu | Doxorubicin | 141.9265 | 20.4547 |
| MDAMB231 | Doxorubicin | 242.127 | 20.6849 |