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. 2019 Oct 4;12:236. doi: 10.3389/fnmol.2019.00236

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Copyright © 2019 Mavrikaki, Pantano, Potter, Rogers-Grazado, Anastasiadou, Slack, Amr, Ressler, Daskalakis and Chartoff.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of housing condition during adolescence on anxiety-like behavior in adulthood as measured in the elevated plus maze (EPM). (A) Experimental design of the study. (B) Male SI and GH rats did not differ in % time spent in open arms (TSOA) [TSOA/(TSOA + closed arm time)], whereas the % TSOA was significantly decreased in SI compared to GH female rats. (C) Male SI and GH rats did not differ in the number of open arm entries (OAE), whereas the number of OAE was significantly decreased in SI compared to GH female rats. (D) Neither male nor female SI and GH rats differed in the number of closed arm entries. n = 9–11/group; GH, group housed; SI, socially isolated; Asterisks indicate significant difference compared to GH control; ^∗∗p < 0.01.