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. 2019 Oct 3;9:978. doi: 10.3389/fonc.2019.00978

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Copyright © 2019 Xie, Wu, Ji, Jiang, Zhang, Ge and Cai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo antitumor effect tested in MGC80-3-bearing mice (n = 5). TP-SMEDDS LDG and Free TP LDG were intragastric administration to mice at the dose of 0.2 mg/kg, TP-SMEDDS MDG and Free TP MDG were intragastric administration to mice at the dose of 0.4 mg/kg, TP-SMEDDS HDG, and Free TP HDG were intragastric administration to mice at the dose of 0.6 mg/kg, and 0.9% saline was used as control. (A) Trend of change in body weight of nude mice; (B) Growth curve of transplanted tumor in nude mice; (C) Representative morphology of transplanted tumors in nude mice of each group. TP-SMEDDS, triptolide-self-microemulsifying drug delivery system; LDG, low-dose group; MDG, medium-dose group; HDG, high-dose group.