Figure 5.

Tumor tissue sections of nude mice treated with different concentrations and dosage forms of TP-SMEDDS. And sections were well-prepared for observation of the pathological change separately under the microscope (×10⁵). TP-SMEDDS LDG and Free TP LDG were intragastric administration to mice at the dose of 0.2 mg/kg, TP-SMEDDS MDG and Free TP MDG were intragastric administration to mice at the dose of 0.4 mg/kg, TP-SMEDDS HDG and Free TP HDG were intragastric administration to mice at the dose of 0.6 mg/kg, and 0.9% saline was used as control. (a) Expression of Ki67 in tumor tissues; (b) Expression of P53 in tumor tissues. TP-SMEDDS, triptolide-self-microemulsifying drug delivery system; LDG, low-dose group; MDG, medium-dose group; HDG, high-dose group.