Fig. 1. Strategies for 89Zr-radiolabelling of Abs. Traditional modification methods based on Lys (A) typically generate heterogeneity. To reduce heterogeneity, these have been extended by methods based on Cys (B), glycans (C) or glutamine targeting (D) using chemical or chemoenzymatic methods. (D) The ‘Q-tag’ system explored in this work has been previously proposed to be exclusively selective for Q298H in antibodies.
