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. 2019 Oct 4;10:2312. doi: 10.3389/fimmu.2019.02312

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Copyright © 2019 Kamermans, Verhoeven, van het Hof, Koning, Borghuis, Witte, van Horssen, de Vries and Rijnsburger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mRNA expression of melanocortin receptors in MS lesions. (A) Expression of MC1-5R mRNA in human white matter control samples shows abundant expression of MC4R (n = 5 per group). (B) No significant differences in mRNA expression of MC4R in control, normal appearing white matter (NAWM), active white matter lesions, and chronic active lesions as performed with one-way ANOVA. (C) In situ HCR reveals presence of MC4R mRNA (white) in GFAP-positive cells (red) in human brain tissue. Nuclei were stained in blue (DAPI). Scale-bar = 20 μm.