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. 2019 Oct 4;10:2326. doi: 10.3389/fimmu.2019.02326

Figure 1.

Figure 1

Certain strains of Lactobacillus inhibit the production of H. pylori-induced TNF and IL-6 in host macrophages. Human macrophages were infected with either H. pylori alone or in combination with lactobacilli. (A) TNF and (B) IL-6 were measured by ELISA in cell culture supernatants after 2, 4, 6, and 8 h of stimulation of THP-1-derived macrophages with Hp alone or in combination with Lactobacillus strains, L. gas, LGG, L. oris, or L. bre. H. pylori alone or in combination with L. gas or L. bre was incubated with MDMs for 8 h. (C) TNF and (D) IL-6 were determined by ELISA. The data presented are representative of results from at least three independent experiments with triplicate samples. Statistical analyses were performed using ANOVA (analysis of variance), followed by Bonferroni posttest. Error bars indicate standard deviation. *P < 0.05 compared with H. pylori alone. Unstim., unstimulated.