Table 1.
Characteristics of the included eight RCTs
| No. of Article | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 |
| First author | Benjamin W. Van Tassell | Allison C. Morton | Antonio Abbate | Antonio Abbate | Antonio Abbate | Robin P. Choudhury | P.M. Ridker | P.M. Ridker |
| Year | 2017 | 2014 | 2010 | 2013 | 2015 | 2016 | 2017 | 2017 |
| Region | America | UK | America | America | America | Canada,UK,America,Germany and Israel | 39 Countries | 39 Countries |
| Trial type | RCT | RCT | RCT | RCT | RCT | RCT | RCT | RCT |
| Drug | Anakinra | Anakinra | Anakinra | Anakinra | Anakinra | Canakinumab | Canakinumab | Canakinumab |
| Case(n[P/T]) | 34(18/16) | 182(89/93) | 10(5/5) | 30(15/15) | 40(20/20) | 189(94/95) | 5628(3344/2284) | 9534(3182/6352) |
| Age (P/T) | 61(56‐68)/57(53‐66) | 61.3(12.3)/61.4(11.7) | 51.8(28‐65)/45.4(34‐59) | 58.2(35‐83)/59.1(46‐86) | 58(51‐65)/57(48‐60) | 61.9(6.9)/61.7(7.8) | 61.1(10.0)/61.2(10.0) | 61.0(54.0‐68.0)/61.0(55.0‐68.0)(T1);61.0(54.0‐68.0)(T2) |
| Male (n[%]) (P/T) | 13(72)/12(75) | 67(75.3)/63(67.7) | 5(100)/3(60) | 13(86.7)/9(60.0) | 18(90)/12(60) | 80(85)/82(86) | 2479(74.1)/1709(74.8) | 2365(74)/4735(75) |
| BMI(kg/㎡) | 30(27‐38)/36(29‐41) | 28.4(4.7)/30.0(7.1) | NA | NA | NA | 30.3(4.0)/30.3(4.1) | NA | 29.7(26.6‐33.9)/30.5(27.0‐34.7)(T1);29.6(26.4‐33.1)(T2) |
| Hypertestion(%) (P/T) | NA | 29(32.6)/31 (33.3) | 3(60)/5(100) | 11(73.3)/7(46.7) | 14 (70)/12(60) | 83(88)/81(85) | 2644(79.1)/1814(79.4) | 2514(79)/5075(80) |
| Diabetes(%)(P/T) | 12(67)/9(56) | 8(9.0)/15(16.1) | 1(20)/2(40) | 3(20.0)/3(20.0) | 4(20)/5(25) | 81(86)/81(85) | 1333(39.9)/1814(79.4) | 1265(40)/2536(40) |
| CRP([mg/L])(P/T) | 5.2(2.0‐11.9)/7.2(3.3‐12.3) | 5.21(3.75, 7.22)/5.38(4.12, 7.04) | NA | 4.3(2.2‐7.5)/7.0(2.3‐8.7) | NA | 1.85(0.83‐3.88)/1.77(0.84‐3.74) | 4.10(2.75‐6.85)/4.25(2.85‐7.05) | 4.10(2.75–6.85)/5.55 (3.60‐9.25)(T1);3.40(2.45‐5.20)(T2) |
| End point | All MACE ALL death AMI UA HF |
All MACE ALL death AMI |
All MACE ALL death AMI UA HF |
All MACE ALL death AMI UA HF |
All MACE ALL death AMI UA HF |
All MACE ALL death AMI UA HF |
All MACE ALL death AMI UA |
All MACE ALL death |
Abbreviations: AMI, acute myocardial infarction; AUC, area under curve; BMI, body‐mass index; CRP, C reactive protein; HF, heart failure; LVESVi, left ventricular end systolic volume index; MACE, major adverse cardiovascular event; NA, not available; P, placebo group; RCT, randomized controlled trial; T, test group; T1, test group1; T2, test group2; UA, unstable angina.