Table 2.
Components of the calcium-calcineurin signaling pathway in C. neoformans, A. fumigatus, C. albicans, and P. falciparum.
| Components | Cryptococcus neoformans | Candida albicans | Aspergillus fumigatus | Plasmodium falciparum |
|---|---|---|---|---|
| Ca++ pumps or channels | ||||
| Cell membrane | Mid1/Cch1 | Mid1/Cch1/Ec m7, Rch1, | CchA/MidA, YvcA | PMCA |
| Vacuolar | Vcx1 | Yvc1 | YvcA | V-type H(+)- |
| Pmc1 | Vcx1 | VcxA | ATPase | |
| Pmc1 | PmcA | |||
| Tfp1 | ||||
| Golgi | Pmr1 | PmrA | ND | |
| Gdt1 | ||||
| ER | Eca1 | Spf1 | ATP6 | |
| Calmodulin | Cam1 | Cmd1 | CamA | CmA |
| Calcineurin | ||||
| Catalytic subunit | Cna1 | Cna1/Cmp1 | CnaA/CalA | CnA |
| Regulatory subunit | Cnb1 | Cnb1 | CnaB | CnB |
| Calcineurin binding proteins | Cbp1 | Rcn1 | CbpA | Cyp |
| Calcineurin targets | ||||
| Calcineurin-regulated TFs | Crz1/SP1 | Crz1 | CrzA | ND |
| Other calcineurin targets | Pbp1, Puf4, Lhp1 | Actin# | ||
| Crz1 target genes | CHS7 | CHS7 | chsA | ND |
| PMC1 | PMC1 | pmcA | ||
#
Potential target
ND, Not determined.